Acute and 28-Day Repeated-Dose Oral Toxicity Assessment of Abelmoschus moschatus Medik. in Healthy Wistar Rats

Figure 2

Photomicrographs of H and E-stained cardiac tissues of the different groups of experimental rats (×400). Healthy control group (a), vehicle 1: corn oil (b), vehicle 2: PVP (c), groups of animals treated with the hexane (d), ethyl acetate (e), butanol (f), and aqueous (g) extracts of A. moschatus at the equivalent therapeutic dose are shown. Repeated oral administration of the selected plant extracts for 28 consecutive days resulted in no significant adverse effects on the histomorphology of cardiac muscle and connective tissue. No signs of necrosis could be observed.

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