Acute and 28-Day Repeated-Dose Oral Toxicity Assessment of Abelmoschus moschatus Medik. in Healthy Wistar Rats

Figure 6

Photomicrographs of H and E-stained sections of kidney tissues of the different groups of experimental rats (×400). Healthy control group (a), vehicle 1: corn oil (b), vehicle 2: PVP (c), groups of animals treated with the hexane (d), ethyl acetate (e), butanol (f), and aqueous (g) extracts of A. moschatus at the equivalent therapeutic dose are shown. Repeated oral administration of the selected plant extracts for 28 consecutive days showed no significant adverse effects on the histomorphology of kidney tissues. Normal morphological architecture was observed with no signs of necrosis or inflammatory cell infiltration. The glomeruli, distal tubules, and proximal tubules appeared normal in all groups with no signs of glomerular congestion or tubular atrophy.

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