Acute and 28-Day Repeated-Dose Oral Toxicity Assessment of Abelmoschus moschatus Medik. in Healthy Wistar Rats
Table 2
Hematological parameters in whole blood after treatment with selected plant extracts of Abelmoschus moschatus for 28 days.
Normal control
Vehicle corn oil
Vehicle PVP
Hexane extract
Ethyl acetate extract
Butanol extract
Aqueous extract
RBC (×106/μL)
7.52 ± 0.14
7.97 ± 0.19
8.20 ± 0.25
8.26 ± 0.22
8.46 ± 0.11a
8.48 ± 0.17a
8.19 ± 0.18
Hb (g/dL)
13.81 ± 0.25
14.04 ± 0.10
13.86 ± 0.14
14.88 ± 0.47
15.06 ± 0.29a
14.38 ± 0.29
14.44 ± 0.23
PCV (%)
50.70 ± 1.03
53.74 ± 0.98
53.86 ± 1.56
53.10 ± 1.88
55.48 ± 0.84
56.16 ± 1.01a
53.84 ± 0.93
PLT (×103/μL)
258.30 ± 17.83
240.00 ± 12.19
243.00 ± 18.23
337.00 ± 23.30a
188.40 ± 5.49a
275.20 ± 21.36
282.60 ± 12.57
WBC (per mm3)
2.40 ± 0.48
2.24 ± 0.48
2.72 ± 0.57
4.46 ± 0.70
4.00 ± 0.20
3.64 ± 0.38
4.58 ± 0.77
Neutrophils (%)
18.33 ± 1.32
18.20 ± 2.48
16.80 ± 2.44
18.60 ± 0.68
20.00 ± 3.78
21.00 ± 4.16
18.40 ± 2.42
Lymphocytes (%)
73.70 ± 2.34
79.00 ± 1.79
73.20 ± 2.22
73.80 ± 2.22
74.80 ± 3.17
71.00 ± 3.83
78.40 ± 2.50
Eosinophils (%)
1.80 ± 0.59
1.20 ± 0.20
1.20 ± 0.20
1.60 ± 0.68
0.80 ± 0.37
0.80 ± 0.20
1.20 ± 0.37
Basophils (%)
1.70 ± 0.26
3.00 ± 0.00
2.40 ± 0.40
1.80 ± 0.58
2.40 ± 0.75
2.20 ± 0.20
1.60 ± 0.51
Monocytes (%)
1.86 ± 0.34
1.20 ± 0.20
1.00 ± 0.00
0.60 ± 0.24
1.20 ± 0.37
1.40 ± 0.24
0.40 ± 0.40a
MCV (fL)
66.83 ± 0.27
66.88 ± 0.31
65.72 ± 0.17
65.76 ± 0.26
67.26 ± 0.26
66.60 ± 0.10
65.82 ± 0.41
MCH (pg)
18.13 ± 0.13
17.66 ± 0.22
17.56 ± 0.14
17.80 ± 0.10
18.22 ± 0.08
17.76 ± 0.08
17.82 ± 0.09
MCHC (g/dL)
27.23 ± 0.20
26.42 ± 0.23a
26.64 ± 0.12
27.04 ± 0.15
27.22 ± 0.11
26.78 ± 0.06
27.10 ± 0.14
Values are expressed as mean ± SEM of ten animals in each group. Results are significant compared to the untreated control group at a,b, and c. RBC: total red blood cell count; Hb: hemoglobin concentration; PCV: packed cell volume; PLT: platelet count; WBC: total white blood cell count; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration.
