In Vitro Evaluation of the Neuroprotective Effect of Panax notoginseng Saponins by Activating the EGFR/PI3K/AKT Pathway

Figure 3

Morphology and cell viability of SH-SY5Y cells after treatment. (a) The morphology of SH-SY5Y cells in each group was observed by inverted microscopy (magnification, 200X, scale bar, 100 μm). The normal group cells adhered to the well and grew in a fusiform or polygonal shape, with round cell bodies and fine synapses. The cell bodies and synapses of the model group were atrophic, and a large number of floating dead cells appeared in the culture dish. There were fewer dead cells in the PNS group and P + A group than in the model group, especially the PNS group. (b) Cell viability was significantly improved in the PNS group compared with the model group () and significantly reduced in the AG1478 group compared with the model group (). The cell viability of the P + A group was significantly lower than that of the PNS group (). Values are expressed as the mean ± SEM (n = 8). vs. model group. vs. PNS group. 8017563

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