NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis

Table 1

The role of NLRP3 inflammasome in AS patients.

Study type	Subjects	Effect of NLRP3 inflammasome	References
Clinical	The ascending aorta tissues of patients with CABG	The expression of NLRP3 is higher than that of patients without AS, which is positively correlated with the lesion degree of AS.	[67]
	Carotid atherosclerotic plaques in human	NLRP3, ASC, caspase-1, IL-1β, and IL-18 are highly expressed, especially in unstable plaques.	[68]
	The plaques of symptomatic AS patients	The expression of NLRP3-mRNA is higher than that of asymptomatic AS patients.	[69]
	The peripheral blood of CHD patients with ACS	The patients with ACS have higher levels of NLRP3 inflammasome.	[70]

CABG: coronary artery bypass grafting; CHD: chronic heart disease; ACS: acute coronary syndrome.