Review Article
NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis
Table 1
The role of NLRP3 inflammasome in AS patients.
| Study type | Subjects | Effect of NLRP3 inflammasome | References |
| Clinical | The ascending aorta tissues of patients with CABG | The expression of NLRP3 is higher than that of patients without AS, which is positively correlated with the lesion degree of AS. | [67] | Carotid atherosclerotic plaques in human | NLRP3, ASC, caspase-1, IL-1β, and IL-18 are highly expressed, especially in unstable plaques. | [68] | The plaques of symptomatic AS patients | The expression of NLRP3-mRNA is higher than that of asymptomatic AS patients. | [69] | The peripheral blood of CHD patients with ACS | The patients with ACS have higher levels of NLRP3 inflammasome. | [70] |
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CABG: coronary artery bypass grafting; CHD: chronic heart disease; ACS: acute coronary syndrome.
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