NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis

Table 2

The effect of NLRP3 inflammasome inhibitors in AS-molded animals.

Study type	Subjects	Inhibitors	Effect	References
In vivo	ApoE^−/− mice fed on a high-fat and high-protein diet	NLRP3 shRNA virus suspension (1.75 × 108 Tfu, 20 μL)	NLRP3 inflammasome inhibited; plaque stability increased; development of AS inhibited	[72]
	ApoE^−/− mice fed on a high-fat diet	Arglabin	The activity of NLRP3 inflammasome inhibited; the production of proinflammatory mediators reduced	[73]
	ApoE^−/− mice	Polyunsaturated fatty acid (vegetable oil and animal oil added into diets for additional 8–16 weeks)	The activation of NLRP3 inflammasome inhibited; the occurrence of AS reduced	[74]
	ApoE^−/− mice	MCC950 (10 mg/kg)	The area of atherosclerotic plaque decreased significantly	[75]