Review Article
NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis
Table 2
The effect of NLRP3 inflammasome inhibitors in AS-molded animals.
| Study type | Subjects | Inhibitors | Effect | References |
| In vivo | ApoE−/− mice fed on a high-fat and high-protein diet | NLRP3 shRNA virus suspension (1.75 × 108 Tfu, 20 μL) | NLRP3 inflammasome inhibited; plaque stability increased; development of AS inhibited | [72] | ApoE−/− mice fed on a high-fat diet | Arglabin | The activity of NLRP3 inflammasome inhibited; the production of proinflammatory mediators reduced | [73] | ApoE−/− mice | Polyunsaturated fatty acid (vegetable oil and animal oil added into diets for additional 8–16 weeks) | The activation of NLRP3 inflammasome inhibited; the occurrence of AS reduced | [74] | ApoE−/− mice | MCC950 (10 mg/kg) | The area of atherosclerotic plaque decreased significantly | [75] |
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