Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract

Table 4

Pharmacokinetic parameters of crocetin plus derivatives that come from the metabolism of crocin isomers.

Parameters	Treatment groups
	affron® 56 mg	affron® 84 mg
Tmax (min)	60	90
Cmax (μg/ml)	0.26 ± 0.12	0.39 ± 0.10
Total AUC(0-3h) (μg·h/ml)	21.07	26.15
T1/2 (h)	0.85 ± 0.04
CL (L/h)	2.70 ± 0.14
Vd (L)	3.19 ± 0.00

Total AUC is calculated on the crocetin concentration change from baseline data. k_e, T_1/2, CL, and Vd are represented as the mean ± SD. T_max = time to maximum concentration; C_max = maximum concentration; AUC = area under the curve; T_1/2 = half-life time; CL  =  clearance; Vd = distribution volume.