Antiplasmodial and Genotoxic Study of Selected Ghanaian Medicinal Plants

Table 4

Mean IC₅₀ of cytotoxicity values and selective indices of the three most active extracts.

Extracts	Mean IC50 (µg/ml) of extracts on PBMCs	Selective index (SI^a) of extracts on Dd2 (%)	Selective index (SI^a) of extracts on 3D7 (%)
A. hispidium DC	3.46 ± 0.25	93.33	94.40
Alstonia boonei	7.58 ± 0.21	209.42	147.78
Senna siamea Lam	7.65 ± 0.22	171.05	193.57

Selective indices (SI^a) = cytotoxicity IC₅₀/antiplasmodial IC₅₀ × 100. The IC₅₀ results are presented as mean ± 2 standard deviations.