Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli

Table 1

Minimum inhibitory concentrations of hexane extract and methanol fraction from M. lowiana.

Strain	MIC (mg/L)
	Hexane extract	Methanol fraction	Ciprofloxacin	Tetracycline	Norfloxacin	Itraconazole	Amphotericin B
S. aureus ATCC 25923	32	32	0.5
S. aureus 13373	64	64	0.5
MRSA 346724	32	32	>32	<1
MRSA 274819	64	64	>32	<1
MSSA 346702	32	64	>32	<1
S. aureus 1199B^a	32	32	16		32
S. aureus XU212^b	64	64		128
E. faecalis 12697	32	32	1	32
E. coli NCTC 10418	>512	>512	<0.0625		1
P. aeruginosa 599	>512	>512	0.25
P. aeruginosa 10662	>512	>512	0.25
K. pneumoniae 342	>512	>512	>32
K. pneumoniae 17	>512	>512	>32
C. albicans ATCC 66027	512	n.t^c				0.125	0.25
C. tropicalis ATCC 750	32	n.t^c				0.125	0.25

^a S. aureus 1199B overexpresses the NorA efflux pump and possesses a gyrase mutation; both contribute to high level resistance to fluoroquinolones. ^bS. aureus XU212 overexpresses a TetK efflux pump that confers resistance to tetracycline and carries the mecA gene that gives rise to beta-lactam resistance. ^cn.t, fraction not tested.