Photoaging Protective Effects of Ranunculus bulumei Methanol Extract

Figure 6

Putative regulatory pathway of Rb-ME mediated antiphotoaging events. UVB-triggered increases in COX-2 and MMP-9 expression, degradation of collagen, and cellular senescence were suppressed by Rb-ME treatment through suppression of the p38/AP-1 pathway. Moisturizing factor expression under normal culture conditions was also elevated by treatment of Rb-ME.