Effect of Huangqin Tang on Urine Metabolic Profile in Rats with Ulcerative Colitis Based on UPLC-Q-Exactive Orbitrap MS
Table 3
The average changes of potential biomarkers (VIP >1) in the urine.
Metabolite
Control
Model
HQT
m-Methylhippuric acid
96.02 ± 14.06
171.94 ± 87.40↑
131.78 ± 65.45↓
5-Hydroxyindoleacetic acid
1.64 ± 0.36
3.30 ± 2.18↑
1.51 ± 0.67#↓
1,2,3-Propanetricarboxylic acid
3.49 ± 0.58
4.48 ± 0.91↑
4.33 ± 0.74↓
Ethanolamine
1.51 ± 0.39
2.03 ± 0.52↑
1.60 ± 0.29#↓
Adipic acid
2.56 ± 0.23
2.92 ± 0.39↑
4.83 ± 1.91
L-isoleucine
9.30 ± 1.92
11.27 ± 1.75↑
11.79 ± 0.31
Pyroglutamic acid
5.20 ± 1.43
7.98 ± 2.68↑
7.34 ± 2.28↓
L-histidine
0.16 ± 0.05
0.25 ± 0.07↑
0.16 ± 0.10#↓
4-Hydroxyproline
0.68 ± 0.11
0.96 ± 0.25↑
1.38 ± 0.33
Sarcosine
0.32 ± 0.04
0.20 ± 0.07↓
0.52 ± 0.16##↑
3-Methylhistidine
0.75 ± 0.11
1.01 ± 0.30↑
1.57 ± 0.54
Gamma-aminobutyric acid
33.97 ± 6.74
46.78 ± 12.31↑
32.65 ± 14.94#↓
Linoleic acid
5.57 ± 1.26
4.45 ± 0.42↓
6.54 ± 2.66#↑
L-valine
40.17 ± 11.32
82.31 ± 42.31↑
73.53 ± 28.53↓
Creatine
7.04 ± 1.94
5.06 ± 0.99↓
6.05 ± 0.98#↑
Cholesterol sulfate
0.15 ± 0.02
0.24 ± 0.07↑
0.22 ± 0.09↓
Arachidonic acid
0.57 ± 0.17
0.39 ± 0.24↓
0.60 ± 0.18#↑
L-tyrosine
0.69 ± 0.12
0.41 ± 0.17↓
0.68 ± 0.25#↑
Palmitoleic acid
5.35 ± 0.82
4.47 ± 0.78↓
6.36 ± 2.23#↑
Alpha-linolenic acid
5.80 ± 1.05
4.64 ± 0.55↓
6.54 ± 2.66↑
Oleic acid
6.87 ± 1.68
5.06 ± 1.24↓
6.73 ± 1.99#↑
Biotin
1.44 ± 0.05
1.85 ± 0.13↑
2.27 ± 1.01
L-proline
0.14 ± 0.04
0.25 ± 0.03↑
0.35 ± 0.02
L-leucine
0.56 ± 0.07
0.71 ± 0.12↑
0.65 ± 0.21↓
Glycine
3.67 ± 0.34
5.83 ± 2.97↑
4.38 ± 2.45↓
D-glucose
3.87 ± 1.02
7.77 ± 7.72↑
6.28 ± 2.30↓
L-serine
11.85 ± 4.54
6.21 ± 2.04↓
9.01 ± 5.01↑
4-Hydroxyphenylacetic acid
23.13 ± 1.82
33.91 ± 6.71↑
31.50 ± 4.56↓
, vs normal control; , vs model group. Arrows indicate upregulated (↑) or downregulated (↓) metabolites in the model group compared with the control group and HQT group compared with model group.
