Yiqi Fumai Injection as an Adjuvant Therapy in Treating Chronic Heart Failure: A Meta-Analysis of 33 Randomized Controlled Trials

Table 1

Baseline characteristics of included studies.

Study	Sample size (T/C)	Male (T/C)	Mean age (T/C)	Cardiac function (T/C)			Interventions in both Yiqi Fumai injection and control group	Dose of Yiqi Fumai injection	Treatment period (weeks)	Outcomes
				NYHA II	NYHA III	NYHA IV
Aunt and Nurbia [15]	60/60	—	55.4 (total)	—	—	—	Furosemide, metoprolol	5.2 g	2	a, b, f
Diao [16]	43/43	22/21	60.3/60.5	—	—	—	Spironolactone, digoxin	—	4	b
Dong and Liu [17]	60/60	38/35	56.4/56.1	—	—	—	Enalapril, metoprolol	5.2 g	2	a, b, e
Feng [18]	27/24	—	56.0∼86.0	12/10	12/12	3/2	Spironolactone, metoprolol	5.2 g	—	b, d
Li [19]	30/30	14/17	67.5/64.7	16/18	14/12	—	Furosemide, metoprolol	1.3 g	2	b
Li et al. [20]	30/30	15/15	71.1/70.9	—	—	—	Ramipril, furosemide	5.2 g	1.5	e, f
Li [21]	30/30	—	64.3 (total)	—	—	—	Furosemide, captopril	2.6 g	4	b, f, g
Li et al. [22]	59/59	35/34	68.5/68.3	—	—	—	Atorvastatin	5.2 g	2	b, e, h
Liu [23]	45/45	24/25	56.7/55.2	/	19/18	26/27	Dobutamine hydrochloride	5.2 g	2	b, e, d, h
Lv [24]	43/40	30/28	62.7/61.5	17/16	14/13	12/11	Furosemide, metoprolol	2.6 g	2	h
Mao and Song [25]	30/30	17/18	58.5/58.6	—	—	—	Spironolactone, metoprolol	2.6 g	2	b, e
Ren [26]	44/44	—	55.0 (total)	—	—	—	Trimetazidine	5.2 g	2	b, e, h
Sun [27]	30/30	11/10	76.0/74.0	6/5	15/17	9/8	Enalapril, metoprolol	3.9 g	2	a, b, e, f, c, g
Sun [28]	60/60	43/44	58.4/58.2	16/17	26/27	18/16	Captopril, metoprolol	5.2 g	2	b, e, h
Wang and He [29]	35/29	19/16	54.9/52.5	9/7	20/18	6/4	Furosemide, digoxin	3.9 g	2	b, c, d, h
Wang [30]	50/50	32/30	70.0/69.5	—	—	—	Aspirin, spironolactone	5.2 g	2	b, e, h
Wang et al. [31]	33/32	19/18	64.3/63.8	—	—	—	Milrinone	5.2 g	1	a, b, e, c
Wang [32]	49/49	32/33	76.0/79.0	—	—	—	Metoprololsuccinate	5.2 g	2	b
Wang and Niu [33]	35/35	21/22	58.0/59.0	10/10	18/19	7/6	Isosorbide dinitrate	3.9 g	2	b, c, h
Wu [34]	32/30	19/17	60.3/62.4	—	—	—	Enalapril	2.1 g	2	b, c
Xi [35]	79/79	39/36	56.0/56.0	—	—	—	Amiodarone, furosemide	2.6 g	2	a
Xue et al. [13]	44/43	28/25	55.3/55.5	7/6	28/28	9/9	Captopril, metoprolol	2.6 g	2	a, b
Yang and Liu [36]	60/60	—	72.2/73.1	6/8	54/52	—	Enalapril, metoprolol	5.8 g	2	b, e
Yang [37]	150/150	89/87	57.2/56.4	29/28	96/97	25/25	Captopril, digoxin	5.2 g	2	b, e, f, h
Yang et al. [38]	30/30	22/23	70.7/70.8	8/5	18/18	4/7	Enalapril, metoprolol	5.2 g	2	b, e
Yang [39]	30/30	16/15	69.0/67.8	6/6	16/18	8/7	Furosemide, metoprolol	2.6 g	2	a
Yu and Wang [40]	30/30	15/16	66.0/65.0	6/6	21/20	3/4	Furosemide, spironolactone	3.9 g	2	b, h
Yu et al. [11]	45/45	25/23	51.5/52.0	—	—	—	Spironolactone, metoprolol	2.6 g	2	a, b
Zhai and Hui [12]	30/30	—	63.0 (total)	20	36	4	Ramipril, furosemide	5.2 g	2	a, b, e, h
Zhang [41]	30/30	—	70.0 (total)	26	20	14	Enalapril, metoprolol	5.2 g	2	a, b, e, f, h
Zhang [10]	40/40	23/24	56.3/55.9	—	—	—	Furosemide, captopril	3.9 g	2	a, b, e
Zhu [42]	100/100	66/66	63.7/63.2	—	—	—	Atorvastatin	5.2 g	2	b, d, h
Zhu and Han [43]	50/50	31/28	66.2/69.0	—	—	—	Aspirin, spironolactone	5.2 g	2	a, b, c, d, g

Notes. Both groups received the same basic treatment; “—” = not reported; T = trial group; C = control group; NYHA = New York Heart Association. Outcomes: a = response rate; b = left ventricular ejection fraction; c = cardiac output; d = left ventricular end-systolic diameter; e = N-terminal pro-brain natriuretic peptide; f = 6-minute walk test; g = quality of life; h = adverse reaction.