System Prediction and Validation of TCM for Chronic Myeloid Leukemia Treatment from the Perspective of Low-Toxicity Chemotherapy: A Stilbene <i>α</i>-Viniferin Has a Proapoptotic Effect on K562 Cells via the Mitochondrial Pathway

<div>Evaluation of mRNA and protein expression of the Bcl-2 family. K562 cells are cultured with 0∼32 <i>μ</i>g·mL<sup>−1</sup><i>α</i>-viniferin for 24 h. (a) Evaluation of mRNA expression of Bcl-2 family by quantitative real-time RT-PCR (qRT-PCR); (b) Evaluation of protein expression of Bcl-2 family by western blotting; relative quantitative analysis of protein expression (c, d). Bcl-2 and Bcl-xL expression decreased, and Bad and Bax expression increased. 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Evidence-Based Complementary and Alternative Medicine

fig8

Figure 8

Figure 8: System Prediction and Validation of TCM for Chronic Myeloid Leukemia Treatment from the Perspective of Low-Toxicity Chemotherapy: A Stilbene <i>α</i>-Viniferin Has a Proapoptotic Effect on K562 Cells via the Mitochondrial Pathway 

Figure 8 | System Prediction and Validation of TCM for Chronic Myeloid Leukemia Treatment from the Perspective of Low-Toxicity Chemotherapy: A Stilbene α-Viniferin Has a Proapoptotic Effect on K562 Cells via the Mitochondrial Pathway 