Lactobacillus Plantarum HFY15 Helps Prevent Retinoic Acid-Induced Secondary Osteoporosis in Wistar Rats

Table 2

Levels of biochemical indicators and cytokines in rats’ serum.

Group	Normal	Model	Zoledronic acid	HFY15
Calcium (mmol/L)	1.30 ± 0.11^b	1.08 ± 0.20^a	1.16 ± 0.14^ab	1.50 ± 0.23^c
Phosphorus (mmol/L)	1.95 ± 0.19^b	1.65 ± 0.19^a	2.38 ± 0.32^c	2.38 ± 0.33^c
BAP (ng/ml)	11.21 ± 0.90^b	9.86 ± 1.52^a	12.66 ± 0.98^c	13.81 ± 1.75^c
BGP (ng/ml)	1.96 ± 0.76^b	1.31 ± 0.39^a	3.26 ± 1.12^c	3.32 ± 1.68^c
IGF-1R (pg/ml)	615.32 ± 115.61^b	320.93 ± 101.72^a	555.48 ± 222.39^b	535.71 ± 259.27^b
TRACP-5b (ng/ml)	0.62 ± 0.36^ab	2.61 ± 0.56^c	0.30 ± 0.20^a	0.70 ± 0.33^b
GABA (umol/L)	7.49 ± 0.31^b	7.10 ± 0.40^a	7.43 ± 0.24^b	7.89 ± 0.39^c

Values presented are the mean ± SD (n = 10/group). Mean values with different superscript letters in the same row are significantly different (). Normal: normal rats control; Model: rats treated with retinoic acid (80 mg/kg/d); Zoledronic Acid: rats treated with retinoic acid (80 mg/kg/d) and single treatment with 0.5 mL/100 g zoledronic acid; HFY15: rats treated with retinoic acid (80 mg/kg/d) and 1 mL/100 g with 10¹⁰ CFU/kg of Lactobacillus plantarum HFY15. BAP: bone-specific alkaline phosphatase. BGP: osteocalcin. IGF-1R: insulin-like growth factor-1 receptor. TRACP-5b: tartrate-resistant acid phosphatase 5b. GABA: γ-aminobutyric acid.