Herb-Drug Interaction: Application of a UPLC-MS/MS Method to Determine the Effect of Polygonum capitatum Extract on the Tissue Distribution and Excretion of Levofloxacin in Rats

Table 4

Recovery and matrix effect of LVFX in rat liver tissues, urine, and feces (n = 5).

Biosamples	Spiked concentration (ng/mL)	Extraction recovery		Matrix effect
		Mean ± SD	RSD (%)	Mean ± SD	RSD (%)
LVFX in liver tissue	10.02	90.84 ± 9.21	10.14	93.09 ± 6.72	7.22
	100.20	89.11 ± 6.24	7.00	103.03 ± 2.50	2.43
	5010.00	89.60 ± 4.69	5.24	97.64 ± 6.08	6.23
LVFX in urine	10.02	94.07 ± 7.88	8.38	93.02 ± 4.09	4.39
	200.40	91.84 ± 10.21	11.11	89.06 ± 6.53	7.33
	4008.00	93.12 ± 5.71	6.14	103.18 ± 9.78	9.48
LVFX in feces	10.02	93.94 ± 8.39	8.93	89.96 ± 4.86	5.41
	20.04	91.36 ± 7.60	8.31	93.00 ± 5.36	5.76
	200.40	101.13 ± 7.14	7.06	92.67 ± 9.76	10.53