Herb-Drug Interaction: Application of a UPLC-MS/MS Method to Determine the Effect of Polygonum capitatum Extract on the Tissue Distribution and Excretion of Levofloxacin in Rats

Table 5

Stability of LVFX under different storage conditions (n = 5).

Biosamples	Spiked concentration (ng/mL)	Calculated concentration (ng/mL)
		Room temperature	Cold storage	Three freeze-thaw cycles
LVFX in liver tissue	10.02	9.36 ± 0.44	9.28 ± 0.85	9.60 ± 0.94
	100.20	102.33 ± 8.31	102.92 ± 10.23	108.10 ± 3.75
	5010.00	4887.83 ± 105.12	4738.62 ± 157.74	4798.11 ± 159.01
LVFX in urine	10.02	8.98 ± 0.97	9.22 ± 0.99	10.50 ± 0.75
	200.40	207.47 ± 10.63	212.35 ± 11.46	197.20 ± 10.17
	4008.00	3869.70 ± 143.60	3888.71 ± 161.29	3833.85 ± 91.54
LVFX in feces	10.02	9.02 ± 0.84	9.74 ± 0.67	9.33 ± 0.82
	20.04	20.96 ± 1.66	18.75 ± 1.19	21.44 ± 0.83
	200.40	192.05 ± 17.68	191.49 ± 18.34	196.81 ± 13.40