Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine
Table 7
Effect of area under the oral glucose tolerance curve values of the polyherbal drug in healthy rats.
Group
Area under the oral glucose tolerance curve values (mmol/L·h)
½ h
1 h
2 h
3 h
4 h
Total
Healthy control rats
3.40 ± 0.07
4.38 ± 0.09
7.32 ± 0.16
5.85 ± 0.06
4.57 ± 0.07
25.52 ± 0.45
Cold water extract (0.5 g/kg)
3.56 ± 0.10
4.24 ± 0.12
6.84 ± 0.19
5.77 ± 0.14
5.19 ± 0.07
25.60 ± 0.62
Cold water extract (1.0 g/kg)
3.48 ± 0.07
4.10 ± 0.08
6.32 ± 0.16
5.24 ± 0.05
4.75 ± 0.15
23.89 ± 0.51
Cold water extract (1.5 g/kg)
3.46 ± 0.05
4.07 ± 0.11
6.29 ± 0.20
5.13 ± 0.12
3.94 ± 0.08
22.89 ± 0.56
Hot water extract (0.5 g/kg)
3.40 ± 0.06
4.00 ± 0.08
6.16 ± 0.15
5.21 ± 0.07
4.10 ± 0.13
22.87 ± 0.49
Hot water extract (1.0 g/kg)
3.38 ± 0.08
4.08 ± 0.11
6.41 ± 0.07
4.67 ± 0.13
3.55 ± 0.14
22.09 ± 0.53
Hot water extract (1.5 g/kg)
3.22 ± 0.06
3.95 ± 0.07
5.96 ± 0.20
4.39 ± 0.10
3.64 ± 0.09
21.16 ± 0.52
Acetone : water extract (0.5 g/kg)
3.36 ± 0.09
4.04 ± 0.09
6.27 ± 0.04
4.75 ± 0.14
3.85 ± 0.19
22.27 ± 0.46
Acetone : water extract (1.0 g/kg)
3.38 ± 0.008
4.08 ± 0.11
6.35 ± 0.05
4.62 ± 0.14
3.49 ± 0.11
21.92 ± 0.41
Acetone : water extract (1.5 g/kg)
3.36 ± 0.09
3.93 ± 0.07a
5.97 ± 0.04
4.54 ± 0.14
3.46 ± 0.11
21.26 ± 0.38
The values are expressed as mean ± SEM (n = 6/group). Data were analyzed by ANOVA followed by Dunnett’s test ( < 0.05). Results are significant compared to the control group at < 0.05.
