Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine
Table 8
Effect of area under the oral glucose tolerance curve values of the polyherbal drug in streptozotocin-induced diabetic rats.
Group
Area under the oral glucose tolerance curve values (mmol/L·h)
½ h
1 h
2 h
3 h
4 h
Total
Healthy control rats
3.44 ± 0.09
3.93 ± 0.17
6.21 ± 0.24
5.23 ± 0.09
4.74 ± 0.04
23.55 ± 0.63
Diabetic control rats
7.42 ± 0.17
8.26 ± 0.23
15.40 ± 0.41
14.17 ± 0.34
13.05 ± 0.39
58.30 ± 1.54
Diabetic rats + cold water extract (0.5 g/kg)
6.86 ± 0.24
7.67 ± 0.08
14.02 ± 0.13
12.06 ± 0.26
11.13 ± 0.46
51.74 ± 1.17
Diabetic rats + cold water extract (1.0 g/kg)
7.17 ± 0.11
7.86 ± 0.12
13.51 ± 0.21
11.45 ± 0.35
9.60 ± 0.25
49.59 ± 1.04
Diabetic rats + cold water extract (1.5 g/kg)
6.78 ± 0.25
7.00 ± 0.27
12.40 ± 0.46
10.38 ± 0.27
4.25 ± 0.36
40.81 ± 1.61
Diabetic rats + hot water extract (0.5 g/kg)
6.93 ± 0.20
7.50 ± 0.25
13.63 ± 0.39
11.92 ± 0.18
10.60 ± 0.19
50.58 ± 1.21
Diabetic rats + hot water extract (1.0 g/kg)
6.75 ± 0.07
7.11 ± 0.06
11.92 ± 0.19
10.73 ± 0.37
9.96 ± 0.49
46.47 ± 1.18
Diabetic rats + hot water extract (1.5 g/kg)
7.04 ± 0.21
7.09 ± 0.16
11.43 ± 0.30
9.63 ± 0.41
8.34 ± 0.19
43.53 ± 1.27
Diabetic rats + acetone : water extract (0.5 g/kg)
7.23 ± 0.05
7.52 ± 0.14
12.08 ± 0.90
10.86 ± 0.82
10.70 ± 0.32
48.39 ± 2.23
Diabetic rats + acetone : water extract (1.0 g/kg)
7.30 ± 0.18
6.88 ± 0.08
10.72 ± 0.28
9.91 ± 0.30
9.12 ± 0.36
43.94 ± 1.20
Diabetic rats + acetone : water extract (1.5 g/kg)
7.36 ± 0.10
7.02 ± 0.15
10.36 ± 0.21
9.01 ± 0.17
8.24 ± 0.20
41.99 ± 0.83
Diabetic rats + glibenclamide (0.5 mg/kg)
7.19 ± 0.19
6.55 ± 0.20
9.22 ± 0.46
7.48 ± 0.30
6.00 ± 0.36
36.44 ± 1.51
The values are expressed as mean ± SEM (n = 6/group). Data were analyzed by ANOVA followed by Dunnett’s test ( < 0.05). Results are significant compared to the control group at < 0.05.
