Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3/NF-kB/IL-6 and VEGF Loop

Figure 1

At-EE had antitumor efficacy in ovarian cancer. (a, b) 3 × 10⁶ cells were injected into the ovarian bursa of BALB/c nude mice, which were randomized into control group and At-EE group. (a) 4 weeks later, cancer cells in the abdominal cavity were counted by in vivo bioluminescence imaging. (b) After the experiment, the mice were sacrificed, and the tumors were resected. (c) 5 × 10⁶ cells were inoculated into ovarian bursa of BALB/c nude mice, which were randomized into control group and At-EE group. (d) The expression of CD31 was detected by immunohistochemical staining. After finishing the experiment, tumor tissues from each mouse were resected for measurement. The results were similar in at least three independent experiments. . .

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