The Therapeutic Effect of Shark Liver Oil in a Rat Model of Acetic Acid-Induced Ulcerative Colitis
Table 3
Effect of different treatments on kidney and liver function of acetic acid-induced rats.
Index
N/S
Gel base
Mesalazine
Asacol
SLO 5%
SLO 10%
SLO 200 mg
SLO 400 mg
Creatinine (mg/dl)
0.62 ± 0.034
0.45 ± 0.022
0.48 ± 0.033
0.54 ± 0.028
0.58 ± 0.064
0.63 ± 0.035
0.62 ± 0.078
0.45 ± 0.061
Urea (mg/dl)
22.60 ± 2.79
20.11 ± 2.42
17.77 ± 2.90
20.26 ± 1.36
21.39 ± 3.73
20.15 ± 2.14
23.21 ± 1.03
22.31 ± 1.06
AST (U/L)
115.6 ± 17.36
111.7 ± 16.06
124.6 ± 17.02
102.3 ± 18.32
130 ± 16.07
128.7 ± 13.29
129.2 ± 34.99
146.3 ± 30.11◉
ALT (U/L)
77.3 ± 20.78
68.75 ± 8.17
59.4 ± 14.09
78.42 ± 10.11
63 ± 18.04
71.55 ± 8.57
77 ± 19.48
84 ± 16.44
ALP (U/L)
711.8 ± 210
726 ± 173
741 ± 149
754 ± 192
627 ± 104
618 ± 125
705 ± 246
733 ± 219
Albumin (g/dl)
3.15 ± 0.14
3.08 ± 0.11
3.11 ± 0.13
3.02 ± 0.11
3.14 ± 0.25
2.98 ± 0.23
3.32 ± 0.18
3.43 ± 0.18
Total protein (g/dl)
6.18 ± 0.38
5.81 ± 0.37
5.75 ± 0.25
5.98 ± 0.22
6.27 ± 0.58
6.04 ± 0.57
6.59 ± 0.11
6.71 ± 0.23
Indirect bilirubin (mg/dl)
0.09 ± 0.023
0.09 ± 0.005
0.08 ± 0.006
0.09 ± 0.006
0.1 ± 0.006
0.09 ± 0.009
0.04 ± 0.08
0.04 ± 0.29
Total bilirubin (mg/dl)
0.13 ± 0.013
0.12 ± 0.019
0.13 ± 0.011
0.13 ± 0.008
0.13 ± 0.003
0.12 ± 0.043
0.06 ± 0.011
0.08 ± 0.036
The analysis was performed using one-way ANOVA and Tukey’s post hoc test. Data are presented as mean ± SD. SLO vs. normal saline; ✝SLO vs. gel base; ◉SLO vs. Asacol.
