Therapeutic Effect of Tetrapanax papyriferus and Hederagenin on Chronic Neuropathic Pain of Chronic Constriction Injury of Sciatic Nerve Rats Based on KEGG Pathway Prediction and Experimental Verification

Figure 4

Hematoxylin-eosin staining of injured nerve. Rats in the sham operation group had intact nerve structure and no inflammatory cell infiltration (a). Proliferation of a large number of Schwann cells was also observed. Moreover, we observed that the normal structure of sciatic nerve was damaged (b). After treatments, we observed a decrease in inflammatory cells and Schwann cell proliferation, but the morphology of the sciatic nerve tissue structure did not return to normal (c–f). All pictures were taken under an optical 400x microscope. (a) Sham operation group. (b) CCI group. (c) Pregabalin group. (d) Mecobalamin group. (e) Tetrapanax papyriferus group. (f) Hederagenin group.

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