Applying Complex Network and Cell-Cell Communication Network Diagram Methods to Explore the Key Cytokines and Immune Cells in Local Acupoint Involved in Acupuncture Treating Inflammatory Pain

Figure 7

Cytokine association network of ST36 acupoint in groups on days 1, 7, and 15. Cytokine association network (correlation coefficients ∈ [−1, −0.8], [0.8, 1]) of the ST36 acupoint in CFA group and CFA + MA group. Green dots represent chemokines, pink dots represent innate immune cytokines, blue dots represent adaptive immune cytokines, and black dots represent growth factors. Red lines represent positive correlation between the cytokines, and blue lines represent negative correlation between the cytokines. The thicker line represents greater correlation coefficient, and the thinner line represents smaller correlation coefficient. (B) CCC network diagram.