Applying Complex Network and Cell-Cell Communication Network Diagram Methods to Explore the Key Cytokines and Immune Cells in Local Acupoint Involved in Acupuncture Treating Inflammatory Pain

<div>CCC network diagram of ST36 acupoint in groups on days 1, 7, and 15. (a) CCC network diagram. The CCC network diagram was mapped in model condition induced by CFA compared with the control group (CFA condition) and the condition of CFA rats treated with MA compared with CFA group (CFA + MA condition). Communication networksd represents the whole immune network density between cells in indicated condition. (b–d) Heat maps of total density of involved cells on days 1, 7, 15, target celln, secretory celln, and cellsd with high value (deep color) were considered as the key cells in the communication network of ST36 acupoint.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 8: Applying Complex Network and Cell-Cell Communication Network Diagram Methods to Explore the Key Cytokines and Immune Cells in Local Acupoint Involved in Acupuncture Treating Inflammatory Pain 

Figure 8 | Applying Complex Network and Cell-Cell Communication Network Diagram Methods to Explore the Key Cytokines and Immune Cells in Local Acupoint Involved in Acupuncture Treating Inflammatory Pain 