Research Article
Antistaphylococcal Activity of Extracts, Fractions, and Compounds of Acacia polyacantha Wild (Fabaceae)
Table 4
MICs (μg/mL) of tested samples in the presence of carbonyl cyanide (m)-chlorophenylhydrazone (CCCP).
| | Bacteria | Tested samples, MIC (μg/mL) in the presence of CCCP and AAF (in parentheses) | | Bark crude extracts | Root extract | Leaf extract | Bark (EAF) | F8 | 3 | 4 | 7 | 10 | Ciprofloxacin |
| | ATCC25923 | 32 (8) | 64 (16) | 64 (8) | 64 (4) | 128 (2) | 16 (8) | 8 (4) | 128 (≥8) | 32 (16) | ≤0.5 (≥1) | | MRSA 3 | ≤4 (≥64) | ≤4 (32) | ≤4 (≥32) | 64 (2) | ≤2 (≥128) | ≤2 (≥16) | ≤2 (≥8) | ≤4 (≥64) | 8 (32) | ≤0.5 (≥4) | | MRSA 4 | 64 (4) | 8 (128) | 32 (4) | ≤4 (≥32) | 128 (4) | ≤2 (≥32) | 16 (4) | 256 (≥4) | 32 (16) | ≤0.5 (≥2) | | MRSA 6 | 16 (64) | 256 (4) | ≤4 (≥64) | 256 (2) | 64 (2) | ≤2 (≥32) | 32 (1) | 8 (16) | 16 (16) | ≤0.5 (≥4) | | MRSA 8 | 128 (4) | 512 (2) | 512 (2) | 512 (≥2) | 64 (4) | ≤2 (≥64) | ≤2 (≥64) | 64 (4) | 64 (8) | ≤0.5 (≥4) | | MRSA 9 | 16 (32) | 512 (2) | 128 (4) | 16 (16) | 64 (2) | 4 (16) | 2 (16) | 16 (4) | 16 (32) | ≤0.5 (≥4) | | MRSA 11 | 512 (2) | 512 (≥ 2) | 512 (1) | 512 (1) | 64 (2) | 16 (4) | 8 (2) | 128 (2) | 64 (4) | ≤0.5 (≥4) | | MRSA 12 | 512 (2) | 512 (≥ 2) | 512 (1) | - (-) | 8 (32) | 32 (4) | 8 (4) | 8 (64) | 8 (64) | ≤0.5 (≥4) | | MSSA 01 | 32 (≥32) | 128 (8) | 256 (2) | 8 (4) | 32 (16) | 16 (2) | 8 (2) | 64 (4) | 8 (32) | ≤0.5 (≥4) | | SA 01 | 16 (32) | 64 (8) | 128 (1) | 128 (1) | 256 (2) | ≤2 (≥64) | ≤2 (≥32) | 32 (8) | 16 (2) | ≤0.5 (≥1) | | SA 07 | 512 (≥2) | ≤4 (≥16) | 512 (≥2) | 64 (≥16) | 128 (2) | 16 (4) | - (≤1) | 64 (≥16) | 16 (4) | ≤0.5 (≥1) | | SA 18 | 16 (2) | 8 (64) | ≤4 (≥4) | ≤4 (≥32) | 64 (2) | ≤2 (≥32) | 16 (4) | 512 (1) | ≤2 (≥8) | ≤0.5 (≥1) | | SA 23 | - (1) | 512 (0.125) | 64 (8) | ≤4 (≥128) | 128 (4) | 16 (16) | - (-) | 32 (4) | 32 (16) | ≤0.5 (≥1) | | SA 88 | 128 (≥128) | 128 (≥8) | 64 (2) | 256 (≥4) | 32 (16) | 32 (16) | 32 (≥32) | 128 (≥8) | 128 (1) | ≤0.5 (≥1) |
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(-): ≥1024 μg/mL; CCCP: carbonyl cyanide m-chlorophenylhydrazone; AAF: activity amelioration factor; in bold are AAF ≥2; MIC: minimum inhibitory concentration; MBC: minimum bactericidal concentration; MRSA: methicillin-resistant Staphylococcus aureus; SA: Staphylococcus aureus; MSSA: methicillin susceptible Staphylococcus aureus; 3: 3-O-méthyl-D-chiro-inositol; 4: epicatechin; 7: 3-O-[β galactopyranosyl-(1 ⟶ 4)-β-D-galactopyranosyl]-oleanolic acid; 10: methyl gallate.
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