Antistaphylococcal Activity of Extracts, Fractions, and Compounds of Acacia polyacantha Wild (Fabaceae)
Table 5
MICs (μg/mL) of tested samples in the presence of chlorpromazine (CPZ).
Bacteria
Tested samples, MIC (μg/mL) in the presence of CPZ and AAFs (in parentheses)
Root extract
3
7
10
Ciprofloxacin
ATCC25923
- (≤1)
- (≤0.12)
- (nd)
64 (8)
≤0.5 (≥1)
MRSA 3
- (≤0.12)
- (≤0.03)
- (≤0.25)
64 (4)
≤0.5 (≥4)
MRSA 4
256 (4)
≤2 (≥32)
- (nd)
64 (8)
≥0.5 (≥2)
MRSA 6
- (≤1)
- (≤0.06)
- (≤0.12)
32 (8)
1 (2)
MRSA 8
- (≤1)
≤2 (≥64)
256 (1)
128 (4)
2 (1)
MRSA 9
- (≤1)
- (≤0.06)
- (≤0.06)
64 (8)
≤0.5 (≥4)
MRSA 11
- (nd)
64 (1)
- (≤0.25)
128 (2)
≤0.5 (≥4)
MRSA 12
- (nd)
- (≤0.12)
- (≤0.5)
64 (8)
2 (1)
MSSA 01
- (≤1)
- (≤0.03)
- (≤0.25)
64 (4)
0.5 (4)
SA 01
- (≤0.5)
- (≤0.12)
- (≤0.25)
64 (0.5)
≤0.5 (≥1)
SA 07
- (≤0.06)
- (≤0.06)
- (nd)
128 (0.5)
≤0.5 (≥1)
SA 18
- (≤0.5)
- (≤0.06)
- (≤0.5)
64 (0.25)
≤0.5 (≥1)
SA 23
- (≤0.06)
- (≤0.12)
- (≤0.12)
128 (4)
≤0.5 (≥1)
SA 88
- (nd)
- (≤0.5)
- (nd)
128 (1)
≤0.5 (≥1)
(-): ≥1024 μg/mL; CCCP: carbonyl cyanide m-chlorophenylhydrazone; AAF: activity amelioration factor; in bold are AAF ≥2; MIC: minimum inhibitory concentration; MBC: minimum bactericidal concentration; MRSA: methicillin-resistant Staphylococcus aureus; SA: Staphylococcus aureus; MSSA: methicillin susceptible Staphylococcus aureus; bark and leaf extracts as well as fraction 8 and compound 4 were tested but were not active; nd: not determined.
