Parameter Results Effect sizes (Hedges’ ) 95%CI Anxiety Categorical moderators Outcome measurement tool STAI 9 −1.534 −2.332, −0.736 Others 7 −0.894 −1.241, −0.547 Reflexology before/after Surgical intervention Before 5 −1.409 −2.083, −0.735 After 5 −1.745 −3.066, −0.427 Intervention type 1 time intervention 9 −1.553 −2.190, −0.915 >1 time intervention 6 −0.849 −1.471, −0.226 Surgical intervention type Cardiovascular intervention 5 −1.060 −1.652, −0.467 Other surgery 5 −2.340 −3.485, −1.195 Random sequence generation High/unclear risk 3 −2.401 −4.737, −0.064 Low risk 13 −0.970 −1.275, −0.666 Allocation concealment High/unclear risk 12 −1.271 −1.812, −0.730 Low risk 3 −1.102 −1.668, −0.536 Sleep quality Outcome measurement tool PSQI 7 − 2.021 −2.931, −1.112 Others 3 − 0.853 −1.158, −0.548 Participant − Hemodialysis group 2 2.850 −4.104, −1.596 Nonhemodialysis group 8 −1.375 −2.119, −0.632 Random sequence generation High/unclear risk 4 −2.032 −3.033, −1.031 Low risk 6 −1.424 −2.395, −0.454 Allocation concealment High/unclear risk 7 −2.085 −2.913, −1.257 Low risk 3 −0.686 −0.981, −0.390 Anxiety Parameter Results Slope 95% CI Continuous moderators Mean age 11 −0.155 −1.790, 1.480 Total length in one time 8 −0.126 −2.217, 1.966 Sleep quality Mean age 8 0.035 −0.049, 0.056 Total length of time 10 −0.346 −0.568, −0.124 Duration 10 −0.256 −0.466, −0.046