Toxicity and Its Mechanism Study of Arecae semen Aqueous Extract in Wistar Rats by UPLC-HDMS-Based Serum Metabolomics

Figure 5

OPLS-DA score plots derived from the UPLC-MS data from serum samples after different doses of ASAE treatment: (a) exhibiting the scatter between 1500 mg/kg/d (blue square) and 4500 mg/kg/d (red triangle) doses of ASAE-induced groups and the control group (green circle) in the ESI negative ion mode, R²X = 0.734, R²Y = 0.989 and Q²(cum) = 0.887 and (b) exhibiting the scatter between 1500 mg/kg/d (blue square) and 4500 mg/kg/d (red triangle) doses of ASAE-induced groups and the control group (green circle) in the ESI positive ion mode, R²X = 0.629, R²Y = 0.994 and Q²(cum) = 0.900.

(a)

(b)