Toxicity and Its Mechanism Study of Arecae semen Aqueous Extract in Wistar Rats by UPLC-HDMS-Based Serum Metabolomics

Table 2

Effects of ASAE on biochemical parameters of rats in the study (n = 6).

	Control group	1500 (mg/kg)	4500 (mg/kg)
BUN (mmol/L)	4.25 ± 0.60	3.98 ± 1.17	4.93 ± 1.40
ALT (U/L)	67.90 ± 13.50	53.70 ± 15.11	48.50 ± 15.83
AST (U/L)	204.78.0 ± 17.36	197.56 ± 20.12	168.80 ± 19.24
CK (U/L)	996.75 ± 145.23	1275.60 ± 347.09	1695.20 ± 223.32
Cr (μmol/L)	33.44 ± 4.16	35.50 ± 5.25	27.00 ± 4.34

Values are mean ± SD. significant difference compared with the control group (one-way ANOVA followed by Dunnett’s test).