Toxicity and Its Mechanism Study of Arecae semen Aqueous Extract in Wistar Rats by UPLC-HDMS-Based Serum Metabolomics
Table 4
Pathway analysis of potential markers identified in serum metabonomics.
Pathway name
Total
Hits
−log(p)
FDR
Impact
Biosynthesis of unsaturated fatty acids
42
4
0.000079
9.4482
0.006385
0
Glycerophospholipid metabolism
30
2
0.014520
4.2322
0.58807
0.24197
Fatty acid biosynthesis
43
2
0.028857
3.5454
0.64258
0
Linoleic acid metabolism
5
1
0.031732
3.4504
0.64258
1
Purine metabolism
68
2
0.066940
2.7040
1
0.02838
Glycerolipid metabolism
18
1
0.110090
2.2065
1
0.01920
Fatty acid elongation in mitochondria
27
1
0.160980
1.8265
1
0
Arachidonic acid metabolism
36
1
0.209270
1.5641
1
0.32601
Fatty acid metabolism
39
1
0.224810
1.4925
1
0
Primary bile acid biosynthesis
46
1
0.260010
1.3470
1
0
Total: the number of all metabolites in the metabolic pathway. Hits: the number of differentiated metabolites selected in the metabolic pathway. Raw : the original calculated value of the enrichment analysis. FDR: the value of FDR in multiplex checking. Impact: the influence value calculated by path topology analysis.
