Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents

Table 1

Antiulcer activity of crude extract of the root of C. macrostachyus on the pyloric ligation ulcer model in rats.

Group	Ulcer index	pH	Acidity in mEq/L	Gastric volume (ml)	Mucus content (μg/g)
NC	21.25 ± 1.7^c1d3e3	2.08 ± 0.17^c3d3e3	60.50 ± 0.76^c3d3e3	3.77 ± 0.14^c3d3e3	73.97 ± 0.36^c3d3e3
CM100	16.92 ± 1.29^d1e2	2.55 ± 0.09^c3d3e3	58.33 ± 0.42^c3d3e3	3.40 ± 0.06^c3d3e3	75.75 ± 0.41^c3d3e3
CM200	13.25 ± 0.72^a1	3.72 ± 0.12^a3b3d3e3	46.00 ± 0.58^a3b3d3e3	2.63 ± 0.07^a3b3d2e3	107.31 ± 0.58^a3b3d3e3
CM400	7.67 ± 2.42^a3b1	5.53 ± 0.07^a3b3c3	21.50 ± 0.43^a3b3c3	2.07 ± 0.08^a3b3c2	173.00 ± 0.28^a3b3c3
OM30	5.75 ± 2.57^a3b2	5.83 ± 0.13^a3b3c3	19.83 ± 0.60^a3b3c3	1.83 ± 0.12^a3b3c3	174.62 ± 0.67^a3b3c3

Values are expressed as Mean ± SEM, n = 6, , , , ^acompared to NC, ^bcompared to CM100, ^ccompared to CM200, ^dcompared to CM400, and ^ecompared to OM30. Statistically analyzed by one-way ANOVA followed by the Tukey test.