Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine

Table 3

Univariate and multivariate analysis for overall survival.

	Univariate analysis		Multivariate analysis
			Model 1		Model 2		Model 3
Variables	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value
Sex
Men	1.79 (1.28–2.51)	<0.001	1.51 (0.90–2.53)	0.116	1.76 (1.03–3.02)	0.04	1.77 (1.01–3.07)	0.045
Women	1.00		1.00		1.00		1.00
Age (years)
<65	1.00		1.00		1.00		1.00
≥65	1.66 (1.18–2.33)	0.003	1.23 (0.85–1.77)	0.266	1.22 (0.85–1.75)	0.290	1.48 (1.01–2.17)	0.046
Smoking history
Never smoker	1.00		1.00		1.00		1.00
Ex-smoker or current smoker	1.76 (1.26–2.44)	<0.001	1.03 (0.61–1.73)	0.912	0.99 (0.59–1.67)	0.973	1.10 (0.65–1.86)	0.723
ECOG-PS
0-1	1.00		1.00		1.00		1.00
≥2	3.01 (2.14–4.23)	<0.001	2.51 (1.71–3.67)	<0.001	2.18 (1.47–3.25)	<0.001	1.73 (1.14–2.63)	0.011
Histological type
Non-squamous-cell carcinoma	1.00		1.00		1.00		1.00
SCC	2.20 (1.44–3.37)	<0.001	1.30 (0.81–2.09)	0.284	1.22 (0.75–1.97)	0.421	1.21 (0.75–1.94)	0.442
Extrathoracic metastasis
No	1.00		1.00		1.00		1.00
Yes	1.69 (1.17–2.43)	0.005	1.90 (1.31–2.77)	<0.001	1.78 (1.22–2.61)	0.003	1.71 (1.17–2.51)	0.006
FACT-G total scores	0.98 (0.97–0.99)	<0.001			0.99 (0.98–1.00)	0.032
PWB	0.93 (0.91–0.95)	<0.001					0.94 (0.91–0.97)	<0.001
SFWB	1.00 (0.98–1.03)	0.715					1.01 (0.97–1.04)	0.716
EWB	0.96 (0.93–0.99)	0.005					0.98 (0.95–1.02)	0.416
FWB	0.97 (0.95–0.99)	0.005					1.01 (0.97–1.04)	0.634
Stage
IIIB	1.00
IV	1.05 (0.53–2.06)	0.890
History of anticancer treatment
No	1
Yes	0.70 (0.45–1.08)	0.103
Treatment
KM monotherapy	1
KM with conventional therapy	1.05 (0.75–1.46)	0.780

Abbreviations: CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; EWB, emotional well-being; FACT-G, Functional Assessment Cancer Therapy-General; FWB, functional well-being; HR, hazard ratio; PS, performance status; PWB, physical well-being; SCC, squamous-cell carcinoma; SFWB, social/family well-being.