Review Article
Physiological Significance of Ion Transporters and Channels in the Stomach and Pathophysiological Relevance in Gastric Cancer
Figure 1
Ion transporters and channels related to acid/base homeostasis and their localization in parietal cells. (a) Normal structure of the oxyntic gland and acid/base homeostasis in the stomach. (b) Multiple ion transporters and channels are located in the parietal cell and are involved in the regulation of the HCl output; these include Clā channels: CFTR, CLC2, CLIC6, and SLC26A9; exchangers: SLC26A7 and AE2; sodium/hydrogen exchangers (NHEs): NHE1, NHE2, and NHE4; potassium (K+) channels: KCNQ1 and Kir4.1/5.1; the Na+-K+-2Clā cotransporter: NKCC1; the Na+- cotransporter: NBCe1; and H+/K+-ATPase. The arrows indicate the direction of ion transport.