Network Pharmacology-Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood-Brain Barrier

<div>QKL protected tight junction degeneration and inhibited HIF-1<i>α</i> and MMP-9 activation. (a–e) Expression of occludin, ZO-1, claudin-5, and VE-cadherin was analyzed by western blotting and corresponding quantitative data. (a, f, g) Expression of HIF-1<i>α</i> and MMP-9 was analyzed by western blotting and corresponding quantitative data. Data are reported as means ± SEM. <svg height="12.1645pt" id="M8" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.5275 64.9458 12.1645" width="64.9458pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.432,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.863,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 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Evidence-Based Complementary and Alternative Medicine

fig6

Figure 6

Figure 6: Network Pharmacology-Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood-Brain Barrier 

Figure 6 | Network Pharmacology-Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood-Brain Barrier 