Anticancer Activity of Modified Tongyou Decoction on Eca109 Esophageal Cancer Cell Invasion and Metastasis through Regulation of the Epithelial-Mesenchymal Transition Mediated by the HIF-1α-Snail Axis

<div>MTD inhibited Eca109 cells proliferation in a direct dose-effect manner in both normoxia and hypoxia. Notes: Relation between MTD concentration and cell inhibition rate showed the same tendency in both normoxia and hypoxia, fitted curve taking on cubic manner. (a) Dose-effect manner in normoxia: inhibition rate reached peak at 2560 μg/mL, equal to the rate at 5120 μg/mL, fitted formula, Y(%) = 9.738836 + 0.064047x + (−2 × 10−5)x2 + (1.93 × 10−9)x3. (b) Dose-effect manner in hypoxia, inhibition rate reached peak at 5120 μg/mL, fitted formula, Y(%) = 9.255399 + 0.061135x + (−2.2 × 10−5)x2 + (2.48 × 10−9)x3.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Anticancer Activity of Modified Tongyou Decoction on Eca109 Esophageal Cancer Cell Invasion and Metastasis through Regulation of the Epithelial-Mesenchymal Transition Mediated by the HIF-1α-Snail Axis

Figure 1 | Anticancer Activity of Modified Tongyou Decoction on Eca109 Esophageal Cancer Cell Invasion and Metastasis through Regulation of the Epithelial-Mesenchymal Transition Mediated by the HIF-1α-Snail Axis 