Gubenzhike Recipe Ameliorates Respiratory Mucosal Immunity in Mice with Chronic Obstructive Pulmonary Disease through Upregulation of the γδT Lymphocytes and KGF Levels

Figure 1

Gubenzhike recipe increased the survival rate and body weight of mice with COPD. Data are presented as mean ± SD. None of the blank control group died. They had smooth fur and gentle breath in moderate frequency and uniform rhythm. Mice of the blank control group behaved normally and gradually gained weight. 10 of the COPD model group died. Fur of mice in the model group was dry and dark, some of which lost. Mice moved and jumped restlessly when exposed to cigarette smoke. In the later stage, they often huddled and curled up, somewhile their whole body trembled. They breathed rapidly even with their mouths open. Their chest and abdomen undulated obviously, and they sometimes nodded irregularly. Body weight of mice with COPD was significantly lower than that of the blank control group (). High-dose and medium-dose Gubenzhike recipe groups had 1 death, respectively, while the low-dose group had 4. Compared with the model group, mice in three Gubenzhike recipe groups had softer and shinier fur, less agitation, slower respiratory rate, and significantly heavier weight ().