Gubenzhike Recipe Ameliorates Respiratory Mucosal Immunity in Mice with Chronic Obstructive Pulmonary Disease through Upregulation of the γδT Lymphocytes and KGF Levels

Figure 6

The secretion of inflammatory factors in mice with COPD was significantly increased and was reduced by Gubenzhike recipe. The levels of IL-6 and IL-13 in serum, BALF, and intestinal mucus of the mice were determined by ELISA according to the manufacturer’s instructions. The IL-6 level in serum of the blank control group was significantly lower than that of the other four groups (), while the content of IL-6 in the high-dose Gubenzhike recipe group was significantly lower than that in the model group (). The IL-6 level in BALF of the model control group was significantly higher than that of the blank control group () and the medium-dose and low-dose Gubenzhike recipe groups (). There was no significant statistical difference in IL-6 level of intestinal mucus and IL-13 level of serum between the groups. The IL-13 level in BALF of the model group was significantly higher than that of the blank control group () and the high-dose and medium-dose Gubenzhike recipe groups (). The IL-13 level in intestinal mucus of the model group was significantly higher than that of the blank control group () and the high-dose, medium-dose, and the low-dose Gubenzhike recipe groups ().

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