Beneficial Effects of Macroporous Resin Extract of Dendrobium candidum Leaves in Rats with Hyperuricemia Induced by a High-Purine Diet

Figure 5

DLE improved TLR4/NF-κB pathway in kidney and liver of the hyperuricemic rats at the 9th week of administration. (a and b) Expression of TLR4 and NF-κB in kidney by immunohistochemistry (ICH) (x400) and semiquantitatively analysed as integrated option density (IOD) in positive area of the microphotograph. (c and d) Expression of TLR4 and NF-κB in kidney by immunohistochemistry (ICH) (x400) and semiquantitatively analysed as integrated option density (IOD) in positive area of the microphotograph. TLR4, toll-like receptor 4; NF-κB, nuclear factor-kappaB; Normal, the normal control group; Model, the model group; DLE-L, low dose of the macroporous resin extract of Dendrobium candidum leaves; DLE-H, high dose of the macroporous resin extract of Dendrobium candidum leaves. The data were expressed as mean ± SD (n = 5). and versus the normal control group; and versus the model group.

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