Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model

Figure 2

EA treatment reduces CPZ-induced demyelination. (a) The protein expression of MBP in each group at weeks 5 and 6. EA treatment significantly increases the expression of myelin-related protein. (b) Bar graph shows the quantification of the MBP expression by western blot (n = 5 for each group). Consistently, (c) immunostaining of MBP shows the effect of promoting remyelination by EA treatment (scale bar = 50 μm). (d and e) Ultrastructure of axon/myelin by TEM. EA treatment significantly increases the percentage of the myelinated axon per image field (scale bar = 2 μm) and decreases the number of swollen axons (black arrows). (f) Scatter plot of individual g-ratio against axonal perimeter (left panel) and the integrated g-ratio values among groups (right panel). All data are represented as means ± SEM (, , and ).

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