Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats

Figure 1

Effect of TGD on blood pressure, left ventricular wet weight, heart rate, and body weight. (a-d) 14-week-old male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs) were obtained. BP and heart rate were recorded for 12 weeks using a noninvasive rat tail blood pressure meter (n = 5 per group). (e) WKY and SHR specimens were sacrificed after dosing for 12 weeks, and the left ventricle was weighed. The bar graph displays the ratio of the left ventricular wet weight to the body weight (n = 5 per group). (f) Each animal’s body weight was recorded weekly for 12 weeks during the experiment (n = 5 per group). All of the above values are shown as mean ± SD. compared with WKY + saline group; compared with WKY + saline group; compared with SHR + saline group; compared with SHR + saline group.

(a)

(b)

(c)

(d)

(e)

(f)