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| HECM plus drugs compared to drugs for stable angina |
| Patient or population: stable angina |
| Setting: community |
| Intervention: HECM plus drugs |
| Comparison: drugs |
Outcome
No. of participants (studies) | Relative effect (95% CI) | Anticipated absolute effects (95% CI) | Certainty |
| Control | HECM∗ | Difference |
Seattle Angina Questionnaire (SAQ)
No. of participants: 61 (1 RCT) | — | The mean seattle Angina Questionnaire was 72.77 scores | — | MD 4.9 scores higher (0.57 higher to 9.23 higher) | ⊕○○○
Very lowa,b,c |
Nitroglycerin Tablets consumption
No. of participants: 61 (1 RCT) | — | The mean nitroglycerin tablets consumption was 45.87 mg | — | MD 5.52 mg lower (10.14 lower to 0.9 lower) | ⊕○○○
Very lowa,b,c |
| GRADE working group grades of evidence |
| High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. |
| Moderate certainty: we are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. |
| Low certainty: our confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect. |
| Very low certainty: we have very little confidence in the effect estimate. The true effect is likely to be substantially different from the estimate of effect. |
| Explanations |
| (a) The trial had an unclear risk of selection bias, detective bias, and other bias also had a high risk of performance bias. |
| (b) Number of cases less than 200. |
| (c) Only one trial included, which was published in China and had a small sample size. |
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