Safety and Efficacy Evaluation of Traditional Chinese Medicine (Qingre-Lishi-Yishen Formula) Based on Treatment of Regular Glucocorticoid Combined with Cyclophosphamide Pulse in Children Suffered from Moderately Severe Henoch–Schonlein Purpura Nephritis with Nephrotic Proteinuria

Table 3

Comparison of adverse events of two groups.

Adverse events	Control group, n = 50	QLYF group, n = 100	χ^2
Total adverse events rate	42 (84%)	66 (66%)	5.357	0.022
Respiratory infection	29 (58%)	37 (37%)	5.966	0.023
Urinary infection	13 (26%)	11 (11%)	5.580	0.031
Infectious diarrhea	3 (6%)	3 (3%)	0.195	0.401
Poor appetite	13 (26%)	10 (10%)	6.573	0.015
Hepatotoxicity	17 (34%)	18 (18%)	4.770	0.040
Cardiotoxicity	18 (36%)	18 (18%)	5.921	0.035
Neutropenia	3 (6%)	0 (0%)	3.444	0.036
Others	10 (20%)	7 (7%)	5.606	0.027

Rare adverse events, such as fungal infection, secondary hypertension, secondary diabetes mellitus, secondary ocular hypertension, and dyslipidemia.