Evidence-Based Complementary and Alternative Medicine

Research Article

Efficacy and Safety of Wenxin Granules and Propafenone in Treatment of Atrial Premature Beats: A Systematic Review and Meta-Analysis

Table 3

Characteristics of included RCTs on Wenxin granules and propafenone for treating atrial premature beats.


Study ID	Sample size	Sex (M/F)	APB duration (units: year)	Age (years, average or range)	Interventions			Outcomes
Study ID	Sample size	Sex (M/F)	APB duration (units: year)	Age (years, average or range)	T	C	Course of the treatment	Outcomes

Shao MF 2012 [12]	T:32 C:30	T:15/17 C:14/16	T:0.03–12 (mean: 2.6) C:0.03–11.5 (mean: 2.4)	T:20–78 (Mean: 56) C:22–76 (Mean: 53)	Propafenone 150 mg Tid po and Wenxin granules 5 g Tid po	Propafenone 150 mg Tid po	4 weeks	①②
Fan YN 2018 [13]	T:30 C:32	T:19/11 C:20/12	NR	T:68.23 ± 12.29 C:66.18 ± 10.63	Propafenone 100 mg Tid po and Wenxin granules 5 g Tid po	Propafenone 100 mg Tid po	4 weeks	①②
Wang HP 2012 [5]	T:60 C:60	62/58	1–9	75.34 ± 4.32	Propafenone 100 mg Tid po and Wenxin granules 9 g Tid po	Propafenone 100 mg Tid po	4 weeks	①②
Zhao S 2013 [4]	T:70 C:70	71/69	NR	75.33 ± 4.31	Propafenone 100 mg Tid po and Wenxin granules 1 package Tid po	Propafenone 100 mg Tid po	4 weeks	①②
Wang XS 2013 [14]	T:42 C:42	T:23/19 C:22/20	0.25–10	T:48.12 ± 3.89 C:47.69 ± 3.54	Propafenone 150 mg Tid po and Wenxin granules 5 g Tid po	Propafenone 150 mg Tid po	4 weeks	①②
Du WF 2008 [15]	T:30 C:30	34/26	NR	>60 (Mean:73.5)	Wenxin granules 1 package Tid po	Propafenone 150 mg Tid po	4 weeks	①②
Li ZM 2010 [16]	T:77 C:51	T:48/29 C:32/19	NR	T:56.32 ± 19.65 C:55.19 ± 17.28	Wenxin granules 9 g Tid po	Propafenone 150 mg Tid po	4 weeks	①②
Meng FH 2013 [17]	T:59 C:59	T:36/23 C:35/24	NR	T:41–77 (Mean: 57) C:40–77 (Mean: 57)	Wenxin granules 9 g Tid po	Propafenone 150 mg Tid po	4 weeks	①②
Li L 2009 [18]	T:96 C:84	T:51/45 C:44/40	NR	T:Mean:63.2 C:Mean:60.9	Wenxin granules 9 g 2–3 times a day po	Propafenone 100–150 mg 2–3 times a day po	15–30 days	①
Cui SZ 2008 [19]	T:60 C:30	NR	NR	T:72.80 ± 12.40 C:70.60 ± 14.40	Wenxin granules 9 g Tid po	Propafenone 100 mg Tid po	4 weeks	①②
Liu JF 2009 [20]	T:75 C:75	T:40/35 C:36/39	NR	T:56.20 ± 5.40 C:54.60 ± 4.90	Wenxin granules 9 g Tid po	Propafenone 100 mg Tid po	4 weeks	①

Outcome: ①Clinical efficiency; ②Drug adverse reactions. ^#T: treatment group; C: control group; M: males; F: females; NR: not reported; APBs: atrial premature beats.