Study on Mechanism of Iridoid Glycosides Derivatives from Fructus Gardeniae in Jiangxi Province by Network Pharmacology

Table 1

Information of potential targets from characteristic high-content bioactive components group of Fructus Gardeniae from Jiangxi province in China.

Molecule	OB (%)	DL	Target	Gene	UniProt ID	Probability(%)
Geniposide	14.64	0.44	MX2 : AA81X2 : AA81microtubule-associated protein tau	MAPT	P10636	75.00
	14.64	0.44	Protein kinase C gamma type	PRKCG	P05129	24.00
	14.64	0.44	Protein kinase C beta type	PRKCB	P05771	24.00
	14.64	0.44	Protein kinase C alpha type	PRKCA	P17252	24.00
	14.64	0.44	Protein kinase C theta type	PRKCQ	Q04759	24.00
	14.64	0.44	Protein kinase C delta-type regulatory subunit	PRKCD	Q05655	24.00
	14.64	0.44	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	24.00
	14.64	0.44	Endothelial PAS domain-containing protein 1	EPAS1	Q99814	24.00
	14.64	0.44	Bcl-2-like protein 1	BCL2L1	Q07817	18.00
	14.64	0.44	Apoptosis regulator Bcl-2	BCL2	P10415	18.00
	14.64	0.44	Bcl-2-like protein 2	BCL2L2	Q92843	18.00
	14.64	0.44	Mu-type opioid receptor	OPRM1	P35372	14.00
	14.64	0.44	Delta-type opioid receptor	OPRD1	P41143	14.00
	14.64	0.44	Kappa-type opioid receptor	OPRK1	P41145	14.00
	14.64	0.44	Nociceptin receptor	OPRL1	P41146	14.00
Gardenoside	52.77	0.12	Microtubule-associated protein tau	MAPT	P10636	68.00
	52.77	0.12	Protein kinase C gamma type	PRKCG	P05129	25.00
	52.77	0.12	Protein kinase C beta type	PRKCB	P05771	25.00
	52.77	0.12	Protein kinase C alpha type	PRKCA	P17252	25.00
	52.77	0.12	Protein kinase C theta type	PRKCQ	Q04759	25.00
	52.77	0.12	Protein kinase C delta-type regulatory subunit	PRKCD	Q05655	25.00
	52.77	0.12	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	16.00
	52.77	0.12	Endothelial PAS domain-containing protein 1	EPAS1	Q99814	16.00
	52.77	0.12	Tyrosine-protein phosphatase nonreceptor type 2	PTPN2	P17706	16.00
	52.77	0.12	Tyrosine-protein phosphatase nonreceptor type 1	PTPN1	P18031	16.00
	52.77	0.12	Tyrosyl-DNA phosphodiesterase 1	TDP1	Q9NUW8	15.00
	52.77	0.12	Mu-type opioid receptor	OPRM1	P35372	14.00
	52.77	0.12	Delta-type opioid receptor	OPRD1	P41143	14.00
	52.77	0.12	Kappa-type opioid receptor	OPRK1	P41145	14.00
	52.77	0.12	Nociceptin receptor	OPRL1	P41146	14.00
Geniposidic acid	19.59	0..41	Microtubule-associated protein tau	MAPT	P10636	74.00
	19.59	0..41	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	29.00
	19.59	0..41	Endothelial PAS domain-containing protein 1	EPAS1	Q99814	29.00
	19.59	0..41	Protein kinase C gamma type	PRKCG	P05129	22.00
	19.59	0..41	Protein kinase C beta type	PRKCB	P05771	22.00
	19.59	0..41	Protein kinase C alpha type	PRKCA	P17252	22.00
	19.59	0..41	Protein kinase C theta type	PRKCQ	Q04759	22.00
	19.59	0..41	Protein kinase C delta-type regulatory subunit	PRKCD	Q05655	22.00
	19.59	0..41	Tyrosyl-DNA phosphodiesterase 1	TDP1	Q9NUW8	21.00
	19.59	0..41	Bcl-2-like protein 1	BCL2L1	Q07817	18.00
	19.59	0..41	Apoptosis regulator Bcl-2	BCL2	P10415	18.00
	19.59	0..41	Bcl-2-like protein 2	BCL2L2	Q92843	18.00
	19.59	0..41	Sodium-dependent noradrenaline transporter	SLC6A2	P23975	14.00
	19.59	0..41	Sodium-dependent dopamine transporter	SLC6A3	Q01959	14.00
	19.59	0..41	Activation peptide fragment 1	F2	P00734	14.00
Genipin 1-gentiobioside	45.58	0.83	Microtubule-associated protein tau	MAPT	P10636	71.00
	45.58	0.83	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	31.00
	45.58	0.83	Endothelial PAS domain-containing protein 1	EPAS1	Q99814	31.00
	45.58	0.83	Tyrosine-protein phosphatase nonreceptor type 2	PTPN2	P17706	20.00
	45.58	0.83	Tyrosine-protein phosphatase nonreceptor type 1	PTPN1	P18031	20.00
	45.58	0.83	Transient receptor potential cation channel subfamily V member 1	TRPV1	Q8NER1	14.00
	45.58	0.83	Activation peptide fragment 1	F2	P00734	13.00
	45.58	0.83	Transient receptor potential cation channel subfamily V member 4	TRPV4	Q9HBA0	13.00
	45.58	0.83	Transient receptor potential cation channel subfamily V member 2	TRPV2	Q9Y5S1	13.00
	45.58	0.83	Tyrosyl-DNA phosphodiesterase 1	TDP1	Q9NUW8	11.00
	45.58	0.83	D (1A) dopamine receptor	DRD1	P21728	10.00
	45.58	0.83	D (1B) dopamine receptor	DRD5	P21918	10.00
	45.58	0.83	Motilin receptor	MLNR	O43193	10.00
	45.58	0.83	Growth hormone secretagogue receptor type 1	GHSR	Q92847	10.00
	45.58	0.83	D (2) dopamine receptor	DRD2	P14416	9.00
Gardoside	—	—	Microtubule-associated protein tau	MAPT	P10636	86.00
	—	—	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	22.00
	—	—	Endothelial PAS domain-containing protein 1	EPAS1	Q99814	22.00
	—	—	Glycine receptor subunit alpha-1	GLRA1	P23415	19.00
	—	—	Glycine receptor subunit alpha-2	GLRA2	P23416	19.00
	—	—	Glycine receptor subunit alpha-3	GLRA3	O75311	19.00
	—	—	Glycine receptor subunit beta	GLRB	P48167	19.00
	—	—	Glycine receptor subunit alpha-4	GLRA4	Q5JXX5	19.00
	—	—	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	P28845	12.00
	—	—	Hydroxysteroid 11-beta-dehydrogenase 1-like protein	HSD11B1L	Q7Z5J1	12.00
	—	—	Tyrosyl-DNA phosphodiesterase 1	TDP1	Q9NUW8	12.00
	—	—	Protein kinase C gamma type	PRKCG	P05129	10.00
	—	—	Protein kinase C beta type	PRKCB	P05771	10.00
	—	—	Protein kinase C alpha type	PRKCA	P17252	10.00
	—	—	Protein kinase C theta type	PRKCQ	Q04759	10.00
Shanzhiside	117.77	0.10	Microtubule-associated protein tau	MAPT	P10636	89.00
	117.77	0.10	Hypoxia-inducible factor 1-alpha	HIF1A	Q16665	19.00
	117.77	0.10	Endothelial PAS domain-containing protein 1	EPAS1	Q99814	19.00
	117.77	0.10	Tyrosyl-DNA phosphodiesterase 1	TDP1	Q9NUW8	14.00
	117.77	0.10	Protein kinase C alpha type	PRKCA	P17252	14.00
	117.77	0.10	Protein kinase C delta-type regulatory subunit	PRKCD	Q05655	14.00
	117.77	0.10	Protein kinase C gamma type	PRKCG	P05129	14.00
	117.77	0.10	Protein kinase C beta type	PRKCB	P05771	14.00
	117.77	0.10	Protein kinase C theta type	PRKCQ	Q04759	14.00
	117.77	0.10	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	P28845	14.00
	117.77	0.10	Hydroxysteroid 11-beta-dehydrogenase 1-like protein	HSD11B1L	Q7Z5J1	14.00
	117.77	0.10	Glycine receptor subunit alpha-1	GLRA1	P23415	10.00
	117.77	0.10	Glycine receptor subunit alpha-2	GLRA2	P23416	10.00
	117.77	0.10	Glycine receptor subunit alpha-3	GLRA3	O75311	10.00
	117.77	0.10	Glycine receptor subunit beta	GLRB	P48167	10.00