Research Article
Study on Mechanism of Iridoid Glycosides Derivatives from Fructus Gardeniae in Jiangxi Province by Network Pharmacology
Table 5
Classification and information on target components-related pathways, direct (top 20).
| Classification | Pathway | value | Annotated genes count |
| Signaling molecules and interaction | Neuroactive ligand-receptor interaction | 4.25E − 24 | 15 | Signal transduction | GPCR downstream signaling | 1.17E − 15 | 15 | Signaling by GPCR | 6.64E − 14 | 15 | Class A/1 (rhodopsin-like receptors) | 9.8E − 14 | 10 | GPCR ligand-binding | 2.95E − 12 | 10 | Peptide ligand-binding receptors | 1.98E − 10 | 7 | G alpha (z) signaling events | 5.01E − 10 | 5 | Dopamine receptors | 5.3E − 09 | 3 | HIF-1 signaling pathway | 2.24E − 08 | 5 | Organismal systems | Inflammatory mediator regulation of TRP channels | 1.38E − 14 | 8 | Dopaminergic synapse | 1.47E − 11 | 7 | Human diseases | Amphetamine addiction | 3.01E − 09 | 5 | EGFR tyrosine kinase inhibitor resistance | 6.47E − 09 | 5 | Morphine addiction | 1.32E − 08 | 5 | Cellular processes | Gap junction | 1.12E − 08 | 5 | Transport of small molecules | Ion channel transport | 7.04E − 12 | 8 | Ligand-gated ion channel transport | 1.95E − 11 | 5 | Transmembrane transport of small molecules | 1.44E − 10 | 10 | Hemostasis | Platelet activation, signaling, and aggregation | 3.32E − 09 | 7 | Disinhibition of SNARE formation | 5.3E − 09 | 3 |
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