Research Article
Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer
Figure 1
The effect of Shenling Baizhu Additive Powder (SLBZ-AP) on pain and survival of mice with bone metastasis of lung cancer (BMLC). (a) Pain behavior of mice was analyzed using paw withdrawal mechanical threshold (g) (PWMT). (b) The survival of animals was observed daily and percent survival was calculated. Vehicle: BMLC mice treated with placebo (saline). L-D: BMLC mice treated with 15 g·kg−1·day−1 SLBZ-AP for 2 weeks. M-D: BMLC mice treated with 30 g·kg−1·day−1 SLBZ-AP for 2 weeks. H-D: BMLC mice treated with 60 g·kg−1·day−1 SLBZ-AP for 2 weeks. Rapamycin: BMLC mice treated with 4 mg·kg−1·day−1 rapamycin for 2 weeks.
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