Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer

Figure 2

H&E staining of the marrow of tibia in mice with BMLC. Tumor cells in H&E staining images can be identified by deep purple color and irregular nuclear shape. Vehicle: BMLC mice treated with placebo (saline). L-D: BMLC mice treated with 15 g·kg⁻¹·day⁻¹ SLBZ-AP for 2 weeks. M-D: BMLC mice treated with 30 g·kg⁻¹·day⁻¹ SLBZ-AP for 2 weeks. H-D: BMLC mice treated with 60 g·kg⁻¹·day⁻¹ SLBZ-AP for 2 weeks. Rapamycin: BMLC mice treated with 4 mg·kg⁻¹·day⁻¹ rapamycin for 2 weeks. (a) Sham. (b) Vehicle. (c) L-D. (d) M-D. (e) H-D. (f) Rapamycin.