Research Article
Antinociceptive Effects of Shenling Baizhu through PI3K-Akt-mTOR Signaling Pathway in a Mouse Model of Bone Metastasis with Small-Cell Lung Cancer
Figure 6
The protein expression of p-AKT, p-mTOR, p-P70S6, and VEGF in the marrow of tibia of mice with BMLC was analyzed by immunohistochemistry. (a) Western blots of p-AKT, p-mTOR, p-P70S6, and VEGF. (b) The p-AKT protein expression. (c) The p-mTOR protein expression. (d) The p-P70S6 protein expression. (e) The VEGF protein expression. Vehicle: BMLC mice treated with placebo (saline). L-D: BMLC mice treated with 15 g·kg−1·day−1 SLBZ-AP for 2 weeks. M-D: BMLC mice treated with 30 g·kg−1·day−1 SLBZ-AP for 2 weeks. H-D: BMLC mice treated with 60 g·kg−1·day−1 SLBZ-AP for 2 weeks. Rapamycin: BMLC mice treated with 4 mg·kg−1·day−1 rapamycin for 2 weeks.
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