The Derivative of Tripterygium wilfordii Hook F—Kunxian Capsule, Attenuated Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Table 1

Clinical and demographic characteristics of patients with rheumatoid arthritis.

Study	Number of participants (male/female)		Age (years)		Intervention		Duration	Outcomes
	Experimental	Control	Experimental	Control	Experimental	Control
Ji [20]	30 (3/27)	30 (5/25)	47.93 ± 11.57	52.30 ± 15.84	KXC 0.6 g bid + control	MTX 10 mg qw, NSAIDs	12 w	①②③④⑤⑥
Jia [22]	30 (9/21)	30 (8/22)	22–70	20–70	KXC 0.6 g tid + control	MTX 10–15 mg qw, folic acid 10 mg qw	12 w	①②③④⑤⑥⑦
Lu et al. [23]	20 (7/13)	20 (8/12)	60–73 (67)	61–72 (66)	KXC 0.3–0.6 g tid + MTX 7.5 mg	MTX 7.5–15 mg qw	24 w	①②③④⑤
Quan and Wang [24]	78	78	54.29 ± 11.08	56.04 ± 11.42	KXC 0.3–0.6 g tid + control	HCQ 0.2 g bid	24 w	④⑤⑥⑦
Zhang and Zhang [21]	36 (13/23)	36 (15/21)	45.6 ± 10.2	46.2 ± 9.8	KXC 0.3 tid + control	MTX 10 mg qw + NSAIDs	12 w	③④⑤⑥
Tian [16]	30 (7/23)	30 (6/24)	61.37 ± 10.43	59.47 ± 11.77	KXC 0.3 g tid + control	LEF 20 mg qd	24 w	④⑤⑥
Liu et al. [18]	50 (4/46)	30 (2/28)	36–62	35–59	KXC 0.6 g tid	LEF 20 mg qn	12 w	④⑤⑥⑦
Lu [19]	30 (11/19)	30 (10/20)	46.31 ± 5.62	47.50 ± 5.71	KXC 0.6 g tid	MTX 10–15 mg qw	6 m	③④⑤
Lin et al. [17]	80 (24/56)	79 (13/66)	52.14 ± 9.70	48.62 ± 13.01	KXC 0.3–0.6 g tid	MTX 10–15 mg qw	12 w	①②③④⑤⑥⑦

Note. KXC: Kunxian Capsule; MTX: methotrexate; LEF: leflunomide; HCQ: hydroxychloroquine; ① TJC: tender joint counts; ② SJC: swollen joint counts; ③ DMS: duration of morning stiffness; ④ ESR: erythrocyte sedimentation rate; ⑤ CRP: C-reactive protein; ⑥ RF: rheumatoid factor; ⑦ CCP: anticyclic citrullinated peptide antibody. Values are mean ± standard deviation (SD).